Norfloxacin is a new broad spectrum of antibacterial activity against both Gram-positive and Gram. negative bacteria. After oral administration of Norfloxacin, it produces high concentrations in the urine, so it has the excellent effect for the treatment of urinary tract infection.
Norfloxacin was studied with respect to clinical effect in 115 patients with the urinary tract infection and the following results were obtained.
1. Excellent efficacy was 53% and efficacy rate was 90% in upper urinary tract infection(UTI). Efficacy rate for 20 patients with upper UTI without the underlying disease was 100%, and in 29 patients with underlying disease efficacy rate was 83%.
2. In upper UTI resistant for other antibiotics, efficacy rate was 78%.
3. In lower UTI excellent efficacy rate was 36% and efficacy rate was 71%.
In gonococcal urethritis excellent efficacy rate was 76% and efficacy rate was 88%.
4. Eliminated rate of bacteria on culture findings were E. coli 93%, pseudononas 89%, proteus 100%, klebsiella 80%, gonococcus 88% and staphylococcus 80%.
5. Mild side effects such as epigastric pain, nausea, dizziness and itching sensation were seen in 5 cases.
We consider Neutam-400 is one of the most effective agents in urinary tract infection.
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